Jacobs Group @ Princeton

We work at the intersection of chemistry and biophysics, using computer simulations and statistical mechanics to study how molecules assemble into higher-order structures.

Simplified models can teach us a lot about complex systems. In our group, we use coarse-grained models to learn the general principles that enable fast and robust self-assembly of biomolecules in living systems. Our goal is to identify strategies for optimizing self-assembly reactions, with diverse applications ranging from protein folding to soft materials engineering. We are also applying coarse-grained models to study mechanisms of spontaneous spatial organization inside living cells. [Read more...]