Jacobs Group @ Princeton

We work at the intersection of chemistry and biophysics, using computer simulations and statistical mechanics to study how molecules assemble into higher-order structures.

In our group, we use coarse-grained models to learn general principles that enable fast and robust self-assembly in living systems. We aim to understand the determinants of spatial organization in biomolecular mixtures and how to optimize kinetic pathways for molecular self-assembly. Applications of our methods range from intracellular biomolecular condensates to soft materials engineering. [Read more...]